REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site)

[Homo sapiens]





Although not drawn on the picture, physical interactions take place between MutSalpha and ExoI.

Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) is part of following pathways: This DNA state is a resulting state in the following reactions:

Reaction Previous state Following state
ExoI loads onto heteroduplex DNA with nick 5' to mismatch (distant site) in Homo sapiens Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens

This DNA state is a previous state in the following reactions:

Reaction Previous state Following state
ExoI excises errorenous strand heteroduplex DNA with nick 5' to mismatch in Homo sapiens Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand in Homo sapiens

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