Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha

[Homo sapiens]





MutS searches binds to DNA in the nucleotide-free or ADP-bound state. The binding of MutS to DNA induces bending of both homo- and heteroduplex DNA. When MutS encounters the mismatch, a bend is turned into a sharp kink. This triggers a conformational change in the protein and the exchange of ADP to ATP.

Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha is part of following pathways: This DNA state is a resulting state in the following reactions:

Reaction Previous state Following state
MutSalpha binds mismatch in heteroduplex DNA with nick 3' to mismatch in Homo sapiens Heteroduplex DNA with nick 3' to mismatch in Homo sapiens Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha in Homo sapiens

This DNA state is a previous state in the following reactions:

Reaction Previous state Following state
MutSalpha interacts with MutLalpha on heteroduplex DNA with nick 3' to mismatch in Homo sapiens Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha in Homo sapiens Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens

References:

Authors Title Journal
Antony E, Hingorani MM Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.
-
Jacobs-Palmer E, Hingorani MM The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair.
-
Lamers MH, Georgijevic D, Lebbink JH, Winterwerp HH, Agianian B, de Wind N, Sixma TK ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.
-
Tessmer I, Yang Y, Zhai J, Du C, Hsieh P, Hingorani MM, Erie DA Mechanism of MutS searching for DNA mismatches and signaling repair.
-
Wang H, Yang Y, Schofield MJ, Du C, Fridman Y, Lee SD, Larson ED, Drummond JT, Alani E, Hsieh P, Erie DA DNA bending and unbending by MutS govern mismatch recognition and specificity.
-

Keywords:
Add your own comment!


There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.