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mitomycin C


Mitomycin C belongs to family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. Mitomycin C is a potent DNA crosslinker. Mechanism of its action is followed by two N-alkylations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'.


Mitomycin C is cause of following DNA damages:
Last modification of this entry: Oct. 5, 2009.

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