REPAIRtoire - a database of DNA repair pathways

Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

XRCC2

X-ray repair complementing defective repair in Chinese hamster cells 2

On chromosome: 7q36.1
Known also as: DKFZp781P0919;


NCBI Gene ID: 7516
NCBI Ensembl Id: ENSG00000196584
MIM Id: (from NCBI OMIM database) 600375
Species: Homo sapiens

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
Diseases related to this gene:
References:

Authors Title Journal
Cartwright R, Tambini CE, Simpson PJ, Thacker J The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. Nucleic Acids Res July 1, 1998
Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. Mutat Res June 23, 1999
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Breast Cancer Res Treat May 23, 2010
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy ML Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Carcinogenesis July 7, 2010
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol July 15, 2010

Last modification of this entry: Oct. 6, 2010.

Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.