REPAIRtoire - a database of DNA repair pathways

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RAD1

RAD1 homolog (S. pombe)

On chromosome: 5p13.2
Known also as: REC1; HRAD1;


NCBI Gene ID: 5810
NCBI Ensembl Id: ENSG00000113456
MIM Id: (from NCBI OMIM database) 603153
Species: Homo sapiens

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Parker AE, Van de Weyer I, Laus MC, Oostveen I, Yon J, Verhasselt P, Luyten WH A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. J Biol Chem July 17, 1998
Freire R, Murguia JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev Aug. 15, 1998
St Onge RP, Udell CM, Casselman R, Davey S The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. Mol Biol Cell June 1, 1999
Zou L, Elledge SJ Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science June 6, 2003

Last modification of this entry: Oct. 6, 2010.

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