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ALKBH3

alkB, alkylation repair homolog 3 (E. coli)

On chromosome: 11p11.2
Known also as: ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793;


NCBI Gene ID: 221120
NCBI Ensembl Id: ENSG00000166199
MIM Id: (from NCBI OMIM database) 610603
Species: Homo sapiens

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
Diseases related to this gene:
References:

Authors Title Journal
Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B Reversal of DNA alkylation damage by two human dioxygenases. Proc Natl Acad Sci U S A Dec. 24, 2002
Sundheim O, Vagbo CB, Bjoras M, Sousa MM, Talstad V, Aas PA, Drablos F, Krokan HE, Tainer JA, Slupphaug G Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J July 26, 2006

Last modification of this entry: Oct. 6, 2010.

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