REPAIRtoire - a database of DNA repair pathways

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PARP1

poly (ADP-ribose) polymerase 1

On chromosome: 1q41-q42
Known also as: PARP; PPOL; ADPRT; ADPRT1; PARP-1; ADPRT 1; pADPRT-1;


NCBI Gene ID: 142
NCBI Ensembl Id: ENSG00000143799
MIM Id: (from NCBI OMIM database) 173870
Species: Homo sapiens

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Menissier-de Murcia J Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. Nucleic Acids Res April 15, 1998
Li B, Navarro S, Kasahara N, Comai L Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem April 2, 2004
Thorslund T, von Kobbe C, Harrigan JA, Indig FE, Christiansen M, Stevnsner T, Bohr VA Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. Mol Cell Biol Sept. 1, 2005
Kanno S, Kuzuoka H, Sasao S, Hong Z, Lan L, Nakajima S, Yasui A A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J April 18, 2007
Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell March 20, 2009

Last modification of this entry: Oct. 6, 2010.

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