REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

POLM

polymerase (DNA directed), mu

On chromosome: 7p13
Known also as: Tdt-N; Pol Mu; FLJ35482;


NCBI Gene ID: 27434
NCBI Ensembl Id: ENSG00000122678
MIM Id: (from NCBI OMIM database) 606344
Species: Homo sapiens

Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Ruiz JF, Lucas D, Garcia-Palomero E, Saez AI, Gonzalez MA, Piris MA, Bernad A, Blanco L Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res Jan. 1, 2004
Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juarez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell Aug. 5, 2005
Juarez R, Ruiz JF, Nick McElhinny SA, Ramsden D, Blanco L A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. Nucleic Acids Res Jan. 1, 2006
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Mejean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Carcinogenesis May 1, 2009
Andrade P, Martin MJ, Juarez R, Lopez de Saro F, Blanco L Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Proc Natl Acad Sci U S A Sept. 22, 2009

Last modification of this entry: Oct. 6, 2010.

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