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XRCC5

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

On chromosome: 2q35
Known also as: KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; FLJ39089;


NCBI Gene ID: 7520
NCBI Ensembl Id: ENSG00000079246
MIM Id: (from NCBI OMIM database) 194364
Species: Homo sapiens

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. J Biol Chem March 5, 1992
Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al. Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J Oct. 17, 1994
Bianchi A, de Lange T Ku binds telomeric DNA in vitro. J Biol Chem July 23, 1999
Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA Ku complex interacts with and stimulates the Werner protein. Genes Dev April 15, 2000
Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. J Hepatol Nov. 1, 2008

Last modification of this entry: Oct. 6, 2010.

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