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RAD51CRAD51 homolog C (S. cerevisiae) |
Known also as: RAD51L2; MGC104277;
| NCBI Gene ID: | 5889 |
| NCBI Ensembl Id: | ENSG00000108384 |
| MIM Id: (from NCBI OMIM database) | 602774 |
| Species: | Homo sapiens |
| This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| French CA, Tambini CE, Thacker J | Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. | J Biol Chem Nov. 14, 2003 |
| Bennett BT, Knight KL | Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. | J Cell Biochem Dec. 15, 2005 |
| Badie S, Liao C, Thanasoula M, Barber P, Hill MA, Tarsounas M | RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. | J Cell Biol May 18, 2009 |
Last modification of this entry: Oct. 6, 2010.
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