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RAD54LRAD54-like (S. cerevisiae) |
Known also as: HR54; hHR54; RAD54A; hRAD54;
| NCBI Gene ID: | 8438 |
| NCBI Ensembl Id: | ENSG00000085999 |
| MIM Id: (from NCBI OMIM database) | 603615 |
| Species: | Homo sapiens |
| The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein. |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Kanaar R, Troelstra C, Swagemakers SM, Essers J, Smit B, Franssen JH, Pastink A, Bezzubova OY, Buerstedde JM, Clever B, Heyer WD, Hoeijmakers JH | Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. | Curr Biol July 1, 1996 |
| Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy ML | Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. | Carcinogenesis July 7, 2010 |
| Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF | Variation within DNA repair pathway genes and risk of multiple sclerosis. | Am J Epidemiol July 15, 2010 |
Last modification of this entry: Oct. 6, 2010.
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