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RBBP8retinoblastoma binding protein 8 |
Known also as: RIM; CTIP;
| NCBI Gene ID: | 5932 |
| NCBI Ensembl Id: | ENSG00000101773 |
| MIM Id: (from NCBI OMIM database) | 604124 |
| Species: | Homo sapiens |
| The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Yu X, Baer R | Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. | J Biol Chem June 16, 2000 |
| Ogbogu U, Brown R | Against doctor's orders: the force and limits of personal autonomy in the health care setting. | Health Law J Jan. 1, 2007 |
| Huertas P, Cortes-Ledesma F, Sartori AA, Aguilera A, Jackson SP | CDK targets Sae2 to control DNA-end resection and homologous recombination. | Nature Oct. 2, 2008 |
Last modification of this entry: Oct. 6, 2010.
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