Welcome! Click here to login or here to register.
 |
|||||||||||||||||||
|
|||||||||||||||||||
 |
|||||||||||||||||||
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 6 |
Known also as: ML8; KU70; TLAA; CTC75; CTCBF; G22P1;
| NCBI Gene ID: | 2547 |
| NCBI Ensembl Id: | ENSG00000196419 |
| MIM Id: (from NCBI OMIM database) | 152690 |
| Species: | Homo sapiens |
| The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A | Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. | J Biol Chem March 5, 1992 |
| Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al. | Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. | EMBO J Oct. 17, 1994 |
| Bianchi A, de Lange T | Ku binds telomeric DNA in vitro. | J Biol Chem July 23, 1999 |
| Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA | Ku complex interacts with and stimulates the Werner protein. | Genes Dev April 15, 2000 |
| Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J | Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. | J Hepatol Nov. 1, 2008 |
Last modification of this entry: Oct. 6, 2010.
Add your own comment!
There is no comment yet.
|
|
|
|