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mfd

mfd

Known also as: ECK1100; JW1100;


NCBI Gene ID: 945681
Species: Escherichia coli strain K-12 substr. MG1655

Mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. [More information is available at EcoGene: EG11619]. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor , is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions . [More information is available at EcoCyc: EG11619].


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Selby CP, Witkin EM, Sancar A Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor. Proc Natl Acad Sci U S A Dec. 15, 1991
Oller AR, Fijalkowska IJ, Dunn RL, Schaaper RM Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli. Proc Natl Acad Sci U S A Nov. 15, 1992
Selby CP, Sancar A Mechanisms of transcription-repair coupling and mutation frequency decline. Microbiol Rev Sept. 1, 1994
Selby CP, Sancar A Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties. J Biol Chem March 3, 1995
Selby CP, Sancar A Structure and function of transcription-repair coupling factor. II. Catalytic properties. J Biol Chem March 3, 1995

Keywords:
Last modification of this entry: Oct. 19, 2010.

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