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RFC1replication factor C (activator 1) 1, 145kDa |
Known also as: A1; RFC; PO-GA; RECC1; MHCBFB; RFC140; MGC51786;
| NCBI Gene ID: | 5981 |
| NCBI Ensembl Id: | ENSG00000035928 |
| MIM Id: (from NCBI OMIM database) | 102579 |
| Species: | Homo sapiens |
| The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Bunz F, Kobayashi R, Stillman B | cDNAs encoding the large subunit of human replication factor C. | Proc Natl Acad Sci U S A Dec. 1, 1993 |
| Uchiumi F, Ohta T, Tanuma S | Replication factor C recognizes 5'-phosphate ends of telomeres. | Biochem Biophys Res Commun Dec. 4, 1996 |
| Wood RD, Shivji MK | Which DNA polymerases are used for DNA-repair in eukaryotes? | Carcinogenesis April 1, 1997 |
| Ryu MJ, Kim BJ, Lee JW, Lee MW, Choi HK, Kim ST | Direct interaction between cohesin complex and DNA replication machinery. | Biochem Biophys Res Commun March 17, 2006 |
Last modification of this entry: Oct. 6, 2010.
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