REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

CUL4A

cullin 4A

On chromosome: 13q34

NCBI Gene ID: 8451
NCBI Ensembl Id: ENSG00000139842
MIM Id: (from NCBI OMIM database) 603137
Species: Homo sapiens

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell June 14, 1996
Liu J, Furukawa M, Matsumoto T, Xiong Y NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell Dec. 1, 2002
Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev Nov. 15, 2008

Last modification of this entry: Oct. 6, 2010.

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