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RFC2replication factor C (activator 1) 2, 40kDa |
Known also as: A1; RFC40; MGC3665;
| NCBI Gene ID: | 5982 |
| NCBI Ensembl Id: | ENSG00000049541 |
| MIM Id: (from NCBI OMIM database) | 600404 |
| Species: | Homo sapiens |
| The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Wood RD, Shivji MK | Which DNA polymerases are used for DNA-repair in eukaryotes? | Carcinogenesis April 1, 1997 |
| Ellison V, Stillman B | Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. | J Biol Chem March 6, 1998 |
| Podust VN, Tiwari N, Stephan S, Fanning E | Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA. | J Biol Chem Nov. 27, 1998 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
| Gupte RS, Weng Y, Liu L, Lee MY | The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. | Cell Cycle Jan. 1, 2005 |
Last modification of this entry: Oct. 6, 2010.
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