REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

nth

Unnamed Gene ID: 947122

Known also as: ECK1629; JW1625;


NCBI Gene ID: 947122
Species: Escherichia coli strain K-12 substr. MG1655

Nth is specific for damaged pyrimidine sites, particularly Thy. [More information is available at EcoGene: EG10662]. Endonuclease III or Nth is a DNA glycosylase that recognizes pyrimidine residues damaged by ring saturation, ring fragmentation or ring contraction. [More information is available at EcoCyc: EG10662].


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Cunningham RP, Weiss B Endonuclease III (nth) mutants of Escherichia coli. Proc Natl Acad Sci U S A Feb. 1, 1985
Weiss B, Cunningham RP Genetic mapping of nth, a gene affecting endonuclease III (thymine glycol-DNA glycosylase) in Escherichia coli K-12. J Bacteriol May 1, 1985
Bailly V, Verly WG Escherichia coli endonuclease III is not an endonuclease but a beta-elimination catalyst. Biochem J March 1, 1987
Kuo CF, McRee DE, Fisher CL, O'Handley SF, Cunningham RP, Tainer JA Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III. Science Oct. 16, 1992
Thayer MM, Ahern H, Xing D, Cunningham RP, Tainer JA Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J Aug. 15, 1995

Last modification of this entry: Oct. 6, 2010.

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