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"A cyclin associated with the CDK-activating kinase MO15."

Makela TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA



Published Sept. 15, 1994 in Nature volume 371 .

Pubmed ID: 8078587

Abstract:
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is dependent on cyclin binding and phosphorylation of a conserved threonine (T161 in Cdc2) mediated by the CDK-activating kinase CAK. A CDK-related kinase, MO15 (ref. 10), has been identified as the catalytic subunit of CAK (refs 11-13). Here we use a yeast two-hybrid screen to show that a new human cyclin (cyclin H) is a MO15-associated protein. Cyclin H is a major MO15 partner in vivo and enhances the kinase activity of MO15 towards Cdk2/cyclin A. These findings demonstrate that a cyclin/kinase complex can function as a regulator of other cyclin/kinase complexes, and suggest that cyclin/kinase cascades may exist.


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Last modification of this entry: Oct. 6, 2010

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