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"The interaction of DNA mismatch repair proteins with human exonuclease I."

Schmutte C, Sadoff MM, Shim KS, Acharya S, Fishel R



Published Aug. 31, 2001 in J Biol Chem volume 276 .

Pubmed ID: 11427529

Abstract:
Exonucleolytic degradation of DNA is an essential part of many DNA metabolic processes including DNA mismatch repair (MMR) and recombination. Human exonuclease I (hExoI) is a member of a family of conserved 5' --> 3' exonucleases, which are implicated in these processes by genetic studies. Here, we demonstrate that hExoI binds strongly to hMLH1, and we describe interaction regions between hExoI and the MMR proteins hMSH2, hMSH3, and hMLH1. In addition, hExoI forms an immunoprecipitable complex with hMLH1/hPMS2 in vivo. The study of interaction regions suggests a biochemical mechanism of the involvement of hExoI as a downstream effector in MMR and/or DNA recombination.


This publication refers to following REPAIRtoire entries:

Genes
Proteins


Last modification of this entry: Oct. 6, 2010

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