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"Expression of yeast O6-methylguanine-DNA methyltransferase (MGMT) gene."

Joo JH, Rho JK, Kim JH, Kim WJ, Choe SY, Park SD



Published June 1, 1995 in Cell Mol Biol (Noisy-le-grand) volume 41 .

Pubmed ID: 7549791

Abstract:
We cloned the full genomic DNA of yeast (Saccharomyces cerevisiae) O6-methylguanine-DNA methyltransferase (MGMT) gene and examined its expression. The expression of yeast MGMT gene is decreased when cells reach stationary phase and cannot be induced by the pretreatment with alkylating agents, methylmethanesulfonate (MMS) or N-methyl-N'-nitroso-N-nitrosoguanidine (MNNG). The transcription initiation site was determined by primer extension analysis. This analysis showed that the authentic start codon is the ATG at position +32 from transcription initiation site.


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Last modification of this entry: Oct. 6, 2010

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