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"A possible yeast homolog of human active-gene-repairing helicase ERCC6+."

Huang ME, Chuat JC, Galibert F



Published May 1, 1994 in Biochem Biophys Res Commun volume 201 .

Pubmed ID: 8198589

Abstract:
We report here the sequencing and identification on the chromosome X of S. cerevisiae of an open reading frame, designated GTA1085, encoding a protein 1085 amino acids in size that displays significant homology to a of helicase subfamily. The highest similarity score is with ERCC6, a human putative helicase involved in the repair of active genes, with 53.3% identity over a stretch of 589 amino acids. This putative protein contains all seven consecutive domains conserved among DNA and RNA helicases. Thus, it apparently constitutes a novel member of this subfamily and might be involved, like ERCC6, in the preferential repair of active genes in yeast.


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Proteins


Last modification of this entry: Oct. 6, 2010

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