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"The multifaceted mismatch-repair system"

Jiricny J.



Published May 7, 2006 in Nat Rev Mol Cell Biol. .

Pubmed ID: 16612326

Abstract:
By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.


This publication refers to following REPAIRtoire entries:

Pathways


Last modification of this entry: Oct. 14, 2008

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