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RECQL5

Protein FULL name:

ATP-dependent DNA helicase Q5 isoform 2 [Homo sapiens].


RECQL5 (Homo sapiens) is product of expression of RECQL5 gene.






FUNCTION: May have an important role in DNA metabolism.

CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.

SUBUNIT: Interacts with TOP3A and TOP3B.

SUBCELLULAR LOCATION: Isoform Beta: Nucleus, nucleoplasm.

SUBCELLULAR LOCATION: Isoform Alpha: Cytoplasm.

SUBCELLULAR LOCATION: Isoform Gamma: Cytoplasm.

TISSUE SPECIFICITY: Ubiquitous.

SIMILARITY: Belongs to the helicase family. RecQ subfamily.

SIMILARITY: Contains 1 helicase ATP-binding domain.

SIMILARITY: Contains 1 helicase C-terminal domain.

WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; [LINK]


NCBI GenPept GI number(s): 51242947
Species: Homo sapiens

Links to other databases:

Database ID Link
Uniprot O94762 O94762
PFAM: - O94762 (Link - using uniprot id)
InterPro: - O94762 (Link - using uniprot id)
CATH: - -
SCOP: - -
PDB: - -


Protein sequence:
MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFV
CMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSL
NSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHL
LSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQ
EDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL
GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL
VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRA
GRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFD
ALVTFCEELGRWGRGHGKSLRAAWCSQVVSRHAEL

RECQL5 (Homo sapiens) is able to recognize following damages:
RECQL5 (Homo sapiens) belongs to following protein families:
References:

Title Authors Journal
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A Genomics Dec. 15, 1998
Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS Nucleic Acids Res Sept. 15, 1999
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Shimamoto A, Nishikawa K, Kitao S, Furuichi Y Nucleic Acids Res April 1, 2000
Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A Genome Res March 1, 2001
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J Genome Res Oct. 1, 2004
A quantitative atlas of mitotic phosphorylation. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP Proc Natl Acad Sci U S A Aug. 5, 2008
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Wang B, Malik R, Nigg EA, Korner R Anal Chem Dec. 15, 2008


Last modification of this entry: Oct. 11, 2010.

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