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Fancm |
Protein FULL name:
Fanconi anemia group M protein homolog [Mus musculus].
Fancm (Mus musculus) is product of expression of Fancm gene.
FUNCTION: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions (By similarity).
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBUNIT: Belongs to the multisubunit FA complex composed of APITD1, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. Interacts with APITD1/CENPS, FAAP24 and EME1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
PTM: Phosphorylated; hyperphosphorylated in response to genotoxic stress (By similarity).
SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
SEQUENCE CAUTION: Sequence=BAD32489.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
| NCBI GenPept GI number(s): |
54112418 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q8BGE5 |
Q8BGE5 |
| PFAM: | - |
Q8BGE5 (Link - using uniprot id) |
| InterPro: | - |
Q8BGE5 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEVLLVAAY EAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLP TGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQ SHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLV VDEAHKALGNYAYCQVVRELVKYTTHFRILALSATPGSDIKAVQQVITNL LIGKIELRSEESPDILPYSHERRVEKLVVPLGEELGAIQKTYIQILETFA SSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFA LCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELSRNEDFMKL YTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWN AKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGK NTKGFTQKEQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQK SPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGN RQVLRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSVQRRPFSSRGG IKASKSNKDGLLSEEEFNLWSRLYRLGDSDQVKGVALPQSHFPSLQEDRV IQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFISIMKMIEGMRH EEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFRPS VDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHS EGEGEDGDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEED NHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTD RAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNA SCSPYPEHEHSPRPVSPASHSAGNSQQNLESNSAKRISHPTEKYCLPGTT HNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDS EPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLRVSGK TLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEEL RTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSG RHSDKEIKDAGGASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSP VKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHL GFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPKRNVLKS PEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTCPRLEHFKGRN RNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQ DSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNM NIFSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDED IRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHS VAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSI TDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSD TSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVDSREITTGLEVISSLRT VHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFIEQMQRLQS MFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQE ETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALN MCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDL NQERQKPDTCLTLGVAMKELS |
Fancm (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. | Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H | DNA Res June 1, 2004 |
| The transcriptional landscape of the mammalian genome. | Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y | Science Sept. 2, 2005 |
Last modification of this entry: Oct. 6, 2010.
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