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MDC1mediator of DNA-damage checkpoint 1 |
Known also as: NFBD1; KIAA0170; MGC166888; DKFZp781A0122;
| NCBI Gene ID: | 9656 |
| NCBI Ensembl Id: | ENSG00000137337 |
| MIM Id: (from NCBI OMIM database) | 607593 |
| Species: | Homo sapiens |
| The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Bakkenist CJ, Kastan MB | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Nature Feb. 1, 2003 |
| Polci R, Peng A, Chen PL, Riley DJ, Chen Y | NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. | Cancer Res Dec. 15, 2004 |
| Miele A, Medina R, van Wijnen AJ, Stein GS, Stein JL | The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. | J Cell Biochem Sept. 1, 2007 |
| Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J | RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. | Cell Nov. 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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