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ERCC3excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) |
Known also as: XPB; BTF2; GTF2H; RAD25; TFIIH;
| NCBI Gene ID: | 2071 |
| NCBI Ensembl Id: | ENSG00000163161 |
| MIM Id: (from NCBI OMIM database) | 133510 |
| Species: | Homo sapiens |
| ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
- XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E (#601675 )
- TRICHOTHIODYSTROPHY, PHOTOSENSITIVE (#601675 )
- XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E (#601675 )
- TRICHOTHIODYSTROPHY, PHOTOSENSITIVE (#601675 )
| Authors | Title | Journal |
| Hwang JR, Moncollin V, Vermeulen W, Seroz T, van Vuuren H, Hoeijmakers JH, Egly JM | A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. | J Biol Chem July 5, 1996 |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Coin F, Oksenych V, Egly JM | Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. | Mol Cell April 27, 2007 |
Last modification of this entry: Oct. 6, 2010.
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