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ERCC3

excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)

On chromosome: 2q21
Known also as: XPB; BTF2; GTF2H; RAD25; TFIIH;


NCBI Gene ID: 2071
NCBI Ensembl Id: ENSG00000163161
MIM Id: (from NCBI OMIM database) 133510
Species: Homo sapiens

ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
Diseases related to this gene:
References:

Authors Title Journal
Hwang JR, Moncollin V, Vermeulen W, Seroz T, van Vuuren H, Hoeijmakers JH, Egly JM A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. J Biol Chem July 5, 1996
Kershnar E, Wu SY, Chiang CM Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem Dec. 18, 1998
Coin F, Oksenych V, Egly JM Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol Cell April 27, 2007

Last modification of this entry: Oct. 6, 2010.

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