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EXO1exonuclease 1 |
Known also as: HEX1; hExoI;
| NCBI Gene ID: | 9156 |
| NCBI Ensembl Id: | ENSG00000174371 |
| MIM Id: (from NCBI OMIM database) | 606063 |
| Species: | Homo sapiens |
| This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Wilson DM 3rd, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE | Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. | Nucleic Acids Res Aug. 15, 1998 |
| Schmutte C, Marinescu RC, Sadoff MM, Guerrette S, Overhauser J, Fishel R | Human exonuclease I interacts with the mismatch repair protein hMSH2. | Cancer Res Oct. 15, 1998 |
| Lee BI, Wilson DM 3rd | The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. | J Biol Chem Dec. 31, 1999 |
| Lee Bi BI, Nguyen LH, Barsky D, Fernandes M, Wilson DM 3rd | Molecular interactions of human Exo1 with DNA. | Nucleic Acids Res Jan. 15, 2002 |
Last modification of this entry: Oct. 6, 2010.
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