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exonuclease 1

On chromosome: 1q42-q43
Known also as: HEX1; hExoI;

NCBI Gene ID: 9156
NCBI Ensembl Id: ENSG00000174371
MIM Id: (from NCBI OMIM database) 606063
Species: Homo sapiens

This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Wilson DM 3rd, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. Nucleic Acids Res Aug. 15, 1998
Schmutte C, Marinescu RC, Sadoff MM, Guerrette S, Overhauser J, Fishel R Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res Oct. 15, 1998
Lee BI, Wilson DM 3rd The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. J Biol Chem Dec. 31, 1999
Lee Bi BI, Nguyen LH, Barsky D, Fernandes M, Wilson DM 3rd Molecular interactions of human Exo1 with DNA. Nucleic Acids Res Jan. 15, 2002

Last modification of this entry: Oct. 6, 2010.

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