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MNAT1menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) |
Known also as: MAT1; TFB3; CAP35; RNF66;
| NCBI Gene ID: | 4331 |
| NCBI Ensembl Id: | ENSG00000020426 |
| MIM Id: (from NCBI OMIM database) | 602659 |
| Species: | Homo sapiens |
| Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Busso D, Keriel A, Sandrock B, Poterszman A, Gileadi O, Egly JM | Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. | J Biol Chem July 28, 2000 |
| Sandrock B, Egly JM | A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. | J Biol Chem Sept. 21, 2001 |
Last modification of this entry: Oct. 6, 2010.
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