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TDG

thymine-DNA glycosylase

On chromosome: 12q24.1

NCBI Gene ID: 6996
NCBI Ensembl Id: ENSG00000139372
MIM Id: (from NCBI OMIM database) 601423
Species: Homo sapiens

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Neddermann P, Gallinari P, Lettieri T, Schmid D, Truong O, Hsuan JJ, Wiebauer K, Jiricny J Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J Biol Chem May 31, 1996
Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell Feb. 9, 1998
Lindahl T, Wood RD Quality control by DNA repair. Science Dec. 3, 1999
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics Feb. 1, 2004

Last modification of this entry: Oct. 6, 2010.

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