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COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

On chromosome: 8q13.1
Known also as: CSN5; JAB1; SGN5; MOV-34; MGC3149;

NCBI Gene ID: 10987
NCBI Ensembl Id: ENSG00000121022
MIM Id: (from NCBI OMIM database) 604850
Species: Homo sapiens

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Claret FX, Hibi M, Dhut S, Toda T, Karin M A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature Oct. 3, 1996
Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem Oct. 24, 1997
Takami T, Terai S, Yokoyama Y, Tanimoto H, Tajima K, Uchida K, Yamasaki T, Sakaida I, Nishina H, Thorgeirsson SS, Okita K Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology May 1, 2005
Cooper EM, Cutcliffe C, Kristiansen TZ, Pandey A, Pickart CM, Cohen RE K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J March 18, 2009

Last modification of this entry: Oct. 6, 2010.

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