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COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) |
Known also as: CSN5; JAB1; SGN5; MOV-34; MGC3149;
| NCBI Gene ID: | 10987 |
| NCBI Ensembl Id: | ENSG00000121022 |
| MIM Id: (from NCBI OMIM database) | 604850 |
| Species: | Homo sapiens |
| The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Claret FX, Hibi M, Dhut S, Toda T, Karin M | A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. | Nature Oct. 3, 1996 |
| Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW | Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. | J Biol Chem Oct. 24, 1997 |
| Takami T, Terai S, Yokoyama Y, Tanimoto H, Tajima K, Uchida K, Yamasaki T, Sakaida I, Nishina H, Thorgeirsson SS, Okita K | Human homologue of maid is a useful marker protein in hepatocarcinogenesis. | Gastroenterology May 1, 2005 |
| Cooper EM, Cutcliffe C, Kristiansen TZ, Pandey A, Pickart CM, Cohen RE | K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. | EMBO J March 18, 2009 |
Last modification of this entry: Oct. 6, 2010.
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