Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

TOPBP1

topoisomerase (DNA) II binding protein 1

On chromosome: 3q22.1
Known also as: TOP2BP1;


NCBI Gene ID: 11073
NCBI Ensembl Id: ENSG00000163781
MIM Id: (from NCBI OMIM database) 607760
Species: Homo sapiens

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Yamane K, Kawabata M, Tsuruo T A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur J Biochem Dec. 15, 1997
Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol Cell Biol June 1, 2003

Last modification of this entry: Oct. 13, 2010.

Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.