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COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
(OMIM ID: 600678)

Known also as: MutS E. COLI HOMOLOG OF 6 - MSH6; HNPCC5


The mismatch-binding factor is a heterodimer of the 100-kD MSH2 and a 160-kD polypeptide called GTBP (for G/T binding protein). Sequence analysis identified GTBP as a new member of the MutS homolog family. Both proteins are required for mismatch-specific binding, a result consistent with the finding that tumor-derived cell lines devoid of either protein are also devoid of mismatch-binding activity.


DNA repair proteins related with COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5 (600678) disease:
Following keywords are related to COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5:

Last modification of this entry: Oct. 11, 2010.

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