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Bujnicki Lab Homepage

MMR: MutLalpha nicks heteroduplex DNA with nick 5' to mismatch

[Homo sapiens]


GO molecular function: 0004520



MutLalpha introduces a nick in the daughter strand in the vicinity of the mismatch. The process is activated by MutSalpha RFC, and PCNA, (Kadyrov, 2006), and probably metal ions (Kadyrov, 2006)(Kosinski, 2009). The ATP binding or ATP hydrolysis by MutLalpha also might have a role in the activation of MutLalpha nuclease activity, but it is still a subject of discussion (Fukui, 2008).
In vitro, RFC, PCNA and a pre-existing nick on either 5' or 3' side of the mismatch, are sufficient to direct the reaction to the daughter strand.


This is the reaction from:
Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens
to
Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens


Involved proteins:
Involved enzymes:
References:

Authors Title Journal
Kadyrov FA, Dzantiev L, Constantin N, Modrich P Endonucleolytic function of MutLalpha in human mismatch repair.
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Fukui K, Nishida M, Nakagawa N, Masui R, Kuramitsu S Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.
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