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crosslink

(base crosslink)





Reference for all kinds of damage that connect two bases covalently to each other. Refers mostly to interstrand crosslinks, but also some cases of protein-DNA crosslinks. Repaired by both HR and NER pathways.



Sources:

References:

Authors Title Journal
Sancar A, Lindsey-Boltz LA, Unsal-KaƧmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem. Jan. 1, 2004

Last modification of this entry: Oct. 9, 2010.

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