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"The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D."

Schrock E, Badger P, Larson D, Erdos M, Wynshaw-Boris A, Ried T, Brody L

Published Jan. 1, 1996 in Hum Genet volume 97 .

Pubmed ID: 8566965

The recently cloned human breast and ovarian cancer susceptibility gene, BRCA1, is located on human chromosome 17q21. We have isolated murine genomic clones containing Brca1 as a first step in generating a mouse model for the loss of BRCA1 function. A mouse genomic library was screened using probes corresponding to exon 11 of the human BRCA1 gene. Two overlapping mouse clones were identified that hybridized to human BRCA1 exons 9-12. Sequence analysis of 1.4 kb of the region of these clones corresponding to part of human exon 11 revealed 72% nucleic acid identity but only 50% amino acid identity with the human gene. The longest of the mouse Brca1 genomic clones maps to chromosome 11D, as determined by two-color fluorescence in situ hybridization. The synteny to human chromosome 17 was confirmed by cohybridization with the mouse probe for the NF1-gene. This comparative study confirms that the relative location of the BRCA1 gene has been conserved between mice and humans.

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Last modification of this entry: Oct. 6, 2010

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