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"Thymine-thymine dimer bypass by yeast DNA polymerase zeta."

Nelson JR, Lawrence CW, Hinkle DC



Published June 14, 1996 in Science volume 272 .

Pubmed ID: 8658138

Abstract:
The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally severely inhibits replication, with an efficiency of approximately 10 percent. In contrast, bypass replication efficiency with yeast DNA polymerase alpha was no more than 1 percent. The Rev3-Rev7 complex is the sixth eukaryotic DNA polymerase to be described, and is therefore called DNA polymerase zeta.


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Proteins


Last modification of this entry: Oct. 6, 2010

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