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"Yeast Ku as a regulator of chromosomal DNA end structure."

Gravel S, Larrivee M, Labrecque P, Wellinger RJ



Published May 1, 1998 in Science volume 280 .

Pubmed ID: 9563951

Abstract:
During telomere replication in yeast, chromosome ends acquire an S-phase-specific overhang of the guanosine-rich strand. Here it is shown that in cells lacking Ku, a heterodimeric protein involved in nonhomologous DNA end joining, these overhangs are present throughout the cell cycle. In vivo cross-linking experiments demonstrated that Ku is bound to telomeric DNA. These results show that Ku plays a direct role in establishing a normal DNA end structure on yeast chromosomes, conceivably by functioning as a terminus-binding factor. Because Ku-mediated DNA end joining involving telomeres would result in chromosome instability, our data also suggest that Ku has a distinct function when bound to telomeres.


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Last modification of this entry: Oct. 6, 2010

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