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"Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment." |
Hara K, Shimizu T, Unzai S, Akashi S, Sato M, Hashimoto H |
Published Dec. 1, 2009 in Acta Crystallogr Sect F Struct Biol Cryst Commun volume 65 .
Pubmed ID: 20054135
Abstract:
| REV7 is involved in various cellular functions including DNA replication, signal transduction and cell-cycle regulation. In DNA replication, REV7 interacts with REV3 and forms DNA polymerase zeta, which plays a central role in error-prone DNA synthesis. REV3 is a catalytic subunit and its activity is stimulated by REV7. To clarify the structural basis of the interaction between REV7 and REV3, human REV7 was crystallized in complex with a REV3 fragment. Two crystal forms were obtained. Crystal forms I and II belonged to space groups P2(1), with unit-cell parameters a = 43.8, b = 50.0, c = 107.3 A, beta = 96.9 degrees , and P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 76.6, c = 118.4 A, respectively. |
This publication refers to following REPAIRtoire entries:
| Genes |
Last modification of this entry: Oct. 6, 2010
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