"DNA Repair in mammalian cells: Mismatched repair: variations on a theme."
Kunz C, Saito Y, Schar P
Complementary base pairing underlies the genetic template function of the
DNA double helix. Therefore, to assure faithful DNA transactions, cells
must adhere to a strict application of the Watson-Crick base pairing
principle.Yet, mispairing does arise in DNA, most frequently as a result
of DNA polymerase errors or base damage. These mismatches need be
rectified to avoid mutation. Sometimes, however, mispairing is actively
induced to trigger mutagenesis. This happens in activated B-lymphocytes,
where the targeted generation and processing of G.U mismatches contributes
to somatic hypermutation and antibody diversification. Non-mutagenic
mismatches arise in heteroduplex intermediates of homologous
recombination, and their processing helps restrict homeologous
recombination. Depending on the type of mismatch and the biological
context of its occurrence, cells must apply appropriate strategies of
repair to properly control mutagenesis. This review will illustrate
conceptual and functional challenges of cellular mismatch correction on
typical examples of mutagenic base-base mismatches. (Part of a
This publication refers to following REPAIRtoire entries:
Last modification of this entry: Dec. 9, 2009
Add your own comment!
There is no comment yet.