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DNA ligase |
Protein FULL name:
NAD-dependent DNA ligase [Escherichia coli UTI89].
DNA ligase (Escherichia coli strain K-12 substr. MG1655) is product of expression of ligA gene.
DNA ligase is involved in:
MMR in Escherichia coli strain K-12 substr. MG1655
- DNA ligase seals DNA (5' directed EcMMR) in Escherichia coli strain K-12 substr. MG1655
- DNA ligase seals DNA (3' directed EcMMR) in Escherichia coli strain K-12 substr. MG1655
Keywords:
- mismatch repair (MMR)
- transcription-coupled repair NER (TCR-NER)
- nucleotide excision repair (NER)
- base excision repair (BER)
- short path BER (SP-BER)
- long path BER (LP-BER)
- global genome repair NER (GGR-NER)
- DNA ligase
FUNCTION: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m).
COFACTOR: Magnesium.
SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
SIMILARITY: Contains 1 BRCT domain.
| NCBI GenPept GI number(s): |
91211748 |
| Species: | Escherichia coli |
Links to other databases:
| Database | ID | Link |
| Uniprot | P15042 |
P15042 |
| PFAM: | - |
P15042 (Link - using uniprot id) |
| InterPro: | - |
P15042 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHP ELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQD RLKSNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVR TIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPR NAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLMQFKAWG LPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQL GFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAG VLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTR EVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMD VDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNAL EKAKETTFARFLYALGVREVGEATAAGLAAYFGTLEALEAASIEELQKVP DVGIVVASHVHNFFAEESNRNVISELLAEGVHWPEPIVINAEEIDSPFAG KTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLA KAQELGIEVIDETEMLRLLGS |
Last modification of this entry: Oct. 19, 2010.
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