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Fpg |
Protein FULL name:
formamidopyrimidine-DNA glycosylase [Escherichia coli].
Fpg (Escherichia coli strain K-12 substr. MG1655) is product of expression of mutM gene.
Fpg is involved in:
BER in Escherichia coli strain K-12 substr. MG1655
Keywords:
FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
CATALYTIC ACTIVITY: Hydrolysis of DNA containing ring-opened 7- methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimidine.
CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
COFACTOR: Binds 1 zinc ion per subunit.
SUBUNIT: Monomer.
DOMAIN: The zinc-finger is necessary for DNA binding.
SIMILARITY: Belongs to the FPG family.
SIMILARITY: Contains 1 FPG-type zinc finger.
| NCBI GenPept GI number(s): |
146545 |
| Species: | Escherichia coli |
Links to other databases:
| Database | ID | Link |
| Uniprot | P05523 |
P05523 |
| PFAM: | - |
P05523 (Link - using uniprot id) |
| InterPro: | - |
P05523 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
IHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYF AQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK |
Fpg (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
Last modification of this entry: Oct. 12, 2010.
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