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Protein FULL name:
endonuclease IV with intrinsic 3'-5' exonuclease activity [Escherichia coli str. K-12 substr. MG1655].
Nfo (Escherichia coli strain K-12 substr. MG1655) is product of expression of nfo gene.
Nfo is involved in:
BER in Escherichia coli strain K-12 substr. MG1655
FUNCTION: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'- phosphooligonucleotide end-products.
COFACTOR: Binds 3 zinc ions. Can also bind manganese.
INDUCTION: Endonuclease IV is induced by agents which generate superoxide radical anions.
SIMILARITY: Belongs to the AP endonuclease 2 family.
Links to other databases:
Nfo (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
Last modification of this entry: Oct. 14, 2010.
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