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Protein FULL name:
Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
Tfb5p (Saccharomyces cerevisiae) is product of expression of TFB5 gene.
FUNCTION: Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits.
SUBUNIT: Component of the TFIIH core complex, which is composed of RAD3, SSL1, SSL2, TFB1, TFB2, TFB4 and TFB5.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the TFB5 family.
This protein can be a part of a given complexes:
Links to other databases:
Last modification of this entry: Oct. 6, 2010.
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