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Protein FULL name:
DNA adenine methylase [Escherichia coli str. K-12 substr. MG1655].
Dam (Escherichia coli strain K-12 substr. MG1655) is product of expression of dam gene.
Dam is involved in:
MMR in Escherichia coli strain K-12 substr. MG1655
FUNCTION: Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + DNA adenine = S- adenosyl-L-homocysteine + DNA 6-methylaminopurine.
SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
Links to other databases:
Last modification of this entry: Oct. 12, 2010.
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