Protein FULL name:
unnamed protein product [Escherichia coli].
RuvB (Escherichia coli strain K-12 substr. MG1655) is product of expression of
RuvB is involved in:
HRR in Escherichia coli strain K-12 substr. MG1655
DDS in Escherichia coli strain K-12 substr. MG1655
FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
ENZYME REGULATION: RuvB possesses weak ATPase activity, which is
stimulated by the ruvA protein in the presence of DNA.
SUBUNIT: Homododecamer composed of two hexameric rings; when bound
to DNA in the presence of ATP and magnesium. Forms a complex with
INDUCTION: Expression of the ruv region is induced by damage to
DNA and is regulated by lexA as part of the SOS response. RuvA and
ruvB are also involved in mutagenesis induced by UV and X
irradiation and by some chemicals.
SIMILARITY: Belongs to the ruvB family.
Links to other databases:
Nucleotide sequencing of the ruv region of Escherichia coli K-12 reveals a LexA regulated operon encoding two genes.
||Benson FE, Illing GT, Sharples GJ, Lloyd RG
Nucleic Acids Res
Jan. 25, 1988
Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination.
||Shinagawa H, Makino K, Amemura M, Kimura S, Iwasaki H, Nakata A
Sept. 1, 1988
RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro.
||Tsaneva IR, Muller B, West SC
Proc Natl Acad Sci U S A
Jan. 15, 1993
A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.
||Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.
Dec. 31, 1996
Processing of recombination intermediates by the RuvABC proteins.
Annu Rev Genet
Jan. 1, 1997
The complete genome sequence of Escherichia coli K-12.
||Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Sept. 5, 1997
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
||Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T
Mol Syst Biol
Jan. 1, 2006
Last modification of this entry: Oct. 6, 2010.
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