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Protein FULL name:
6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase., Methylated-DNA-protein-cysteine methyltransferase,
Ogt (Escherichia coli strain K-12 substr. MG1655) is product of expression of ogt gene.
Ogt is involved in:
DRR in Escherichia coli strain K-12 substr. MG1655
FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Can also repair O-4-methylthymine.
CATALYTIC ACTIVITY: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L- cysteine.
MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocytalyst that acts repeatedly and over many reaction cycles.
SIMILARITY: Belongs to the MGMT family.
Links to other databases:
Ogt (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
Last modification of this entry: Nov. 11, 2010.
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