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Protein FULL name:
AidB (Escherichia coli strain K-12 substr. MG1655) is product of expression of aidB gene.
AidB is involved in:
DDS in Escherichia coli strain K-12 substr. MG1655
Upon exposure to alkylating agents, Escherichia coli increases expression of aidB along with three genes (ada, alkA, and alkB) that encode DNA repair proteins. While the biological roles of Ada, AlkA and AlkB proteins have been defined, despite many efforts, the molecular functions of AidB remain largely unknown. In this study, we focused on the biological role of the AidB protein and we demonstrated that AidB shows preferential binding to a DNA region that includes the upstream element of its own promoter, PaidB. The physiological significance of this specific interaction was investigated by in vivo gene expression assays demonstrating that AidB can repress its own synthesis during the normal cell growth. We also showed that the domain architecture of AidB is related to the different functions of the protein: the N-terminal region comprising the first 439 amino acids (AidB 'I-III') possesses FAD-dependent dehydrogenase activity while its C-terminal domain corresponding to residues 440-541 (AidB 'IV') displays DNA binding activity and can negatively regulate the expression of its own gene in vivo.
INDUCTION: By alkylating agents.
SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
SEQUENCE CAUTION: Sequence=AAA97083.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAC18889.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Links to other databases:
AidB (Escherichia coli strain K-12 substr. MG1655) belongs to following protein families:
Last modification of this entry: Oct. 18, 2010.
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