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Protein FULL name:
three prime repair exonuclease 2 isoform a; expressed-Xq28STS protein; 26S proteasome-associated UCH interacting protein 1; 3'-5' exonuclease; Xq28, 2000bp sequence contg. ORF [Homo sapiens].
TREX2 (Homo sapiens) is product of expression of TREX2 gene.
FUNCTION: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.
CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates.
COFACTOR: Magnesium. Required for activity. Substitution with Mn(2+) results in partial activity.
BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5-8.0;
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
SIMILARITY: Belongs to the exonuclease superfamily. TREX family.
CAUTION: The gene for this protein is either identical to or adjacent to that of UCHL5IP. Most mRNAs that encode UCHL5IP also include the N-terminal part of TREX2.
WEB RESOURCE: Name=NIEHS-SNPs; [LINK]
Links to other databases:
TREX2 (Homo sapiens) is able to recognize following damages:
Last modification of this entry: Oct. 11, 2010.
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