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Protein FULL name:
mismatch repair endonuclease PMS2 [Mus musculus].
Pms2 (Mus musculus) is product of expression of Pms2 gene.
FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with Mlh1 to form MutL alpha. DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (Msh2- Msh6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MulL alpha (Mlh1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages (By similarity).
SUBUNIT: Heterodimer of PMS2 and Mlh1 (MutL alpha). Forms a ternary complex with MutS alpha (Msh2-Msh6) or MutS beta (Msh2- Msh3).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
Links to other databases:
Pms2 (Mus musculus) belongs to following protein families:
Last modification of this entry: Oct. 6, 2010.
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